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From the 2003 Guide: What About Multivitamins?
Supplement Guide


Fat-Soluble Vitamins
Fat cells absorb vitamins A, D, E and K and store them in your fat tissue and liver. Getting enough of these vitamins is important, but make sure your diet and supplements don't exceed recommendations. Excesses of these vitamins are stored, rather than excreted, so you can have too much in your system, which can cause negative effects.

Vitamin A
Other names: Beta-carotene, retinal, retinol and retinoic acid. Vitamin A palmitate and vitamin A acetate are retinol forms. "Retinoids" collectively refers to different forms of vitamin A.
Why: Maintains the immune system; protects eyesight; keeps skin and tissues of the mouth, stomach, intestine and respiratory system healthy; acts as an antioxidant.
How much: RDA = 3,000 IU for men; 2,333 IU for women.
Too much: UL = 10,000 IU from retinol. High levels are associated with bone fractures, liver abnormalities and birth defects. Other signs: headaches; dry, itchy skin; hair loss; bone and joint pain; and vomiting and appetite loss.
Too little: Rare; symptoms include night blindness and weakened immune system.
Foods: Beta-carotene: apricots, cantaloupe, carrots, dark leafy greens and sweet potato. Retinol: cheese, liver, eggs and fortified milk.
Supplements: If you take supplements, be sure to look for one with no more than 100% DV, retinol and beta-carotene combined, of which 20 to 50 percent is from beta-carotene.
Interactions: Cholestyramine (Questran), colestipol and mineral oil can reduce vitamin A absorption, while oral contraceptives can increase levels. Supplements combined with isotretinoin (Accutane) can increase drug's toxicity.
Research note: Researchers found that high levels of vitamin A from retinol (not beta-carotene) significantly increased bone fractures among men, confirming research showing that high levels of vitamin A from retinol raised the risk of hip fractures in women.

Vitamin D
Other names: Cholecalciferol, calciferol, ergocalciferol, dihydroxyvitamin
D-2 or D-3.
Why: Builds and maintains strong teeth and bones; protects against osteoporosis; aids in calcium absorption; helps utilize phosphorus. Both calcium and phosphorus are important for bone mineralization.
How much: RDA = 200 IU for adults through age 50; 400 IU from 51 to 70 years of age; 600 IU over age 70.
Too much: UL = 2,000 IU: nausea, vomiting, poor appetite, constipation, weakness and weight loss; increases blood levels of calcium, causing confusion, heart rhythm abnormalities or calcinosis and deposits of calcium in soft tissues.
Too little: A high risk of osteoporosis. Low levels lead to muscle weakness, which can cause older people to tire easily and fall.
Foods: Fortified milk and breakfast cereals are best bets; small amounts also are in egg yolks, butter, salmon, tuna and sardines.
Supplements: Because vitamin D needs increase with age, many experts recommend as much as 800 IU for seniors. Just 10 to 15 minutes of sun exposure two to three times a week (without sunscreen) is enough to fill your reservoir. If you don't get enough sun, consider a supplement.
Interactions: Corticosteroids, such as prednisone, antacids that contain magnesium, cholestyramine (Questran) and mineral oil can interfere with vitamin D absorption.
Research note: In a study of 221 people with knee osteoarthritis (OA), those who increased their daily vitamin D intake gained muscle strength and improved physical function. A study shows daily supplements increase calcium absorption by 65%.

Vitamin E
Other names: Alpha-tocopherol, gamma-tocopherol, tocopherol acetate and tocopherol succinate.
Why: Acts as a scavenger, cleaning up free radicals; also aids in the formation of red blood cells, reproduction and growth.
How much: RDA = 15 mg for adults.
Too much: UL = 1,000 mg daily. May cause increased bleeding time.
Too little: Associated with fat malabsorption diseases like Crohn's disease.
Foods: Peanut butter, almonds, sunflower seeds, margarine, wheat germ, corn oil, soybean oil and turnip greens.
Supplements: Look for mixed tocopherols, natural vitamin E, generally labeled "D." The synthetic form "D,L" is only half as active.
Interactions: Blood-thinning medications, aspirin, NSAIDs and drugs for schizophrenia or chemotherapy.
Research note: A 2004 review of 19 clinical studies sparked a debate about the safety of vitamin E supplementation. However, a closer look showed most of the people who experienced negative effects were elderly and had chronic illnesses. A study of 136 people with knee OA found that supplemental vitamin E didn't have any beneficial effect.

Vitamin K
Other names: Phylloquinone (K-1), menaquinone (K-2), menadione (K-3) and dihydrophylloquinone.
Why: Aids blood clotting and activates osteocalcin, a protein that builds and strengthens bones.
How much: RDA for vitamin K = 90 mcg for women; 120 mcg for men.
Too much: No UL set.
Too little: Too little vitamin K increases blood clotting time and can cause bruises beneath skin and bleeding gums.
Foods: Leafy greens.
Supplements: Multivitamins often contain amounts lower than the RDA because vitamin K may have a blood-clotting effect.
Interactions: Antibiotics can decrease vitamin K production. Excess vitamin K intake may decrease effectiveness of blood-thinning drugs.
Research note: A study of more than 72,000 women found a link between low dietary vitamin K intake and an increased risk of hip fracture. Women who ate iceberg or romaine lettuce one or more times daily were 45-percent less likely to break a hip than those who ate lettuce once a week or less.

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